Anti-human immunodeficiency virus type 1 activities of U-90152 and U-75875 in human brain cell cultures.

Abstract

Antiviral activities of the reverse transcriptase inhibitors U-90152 and 3'-azido-2',3'-dideoxythymidine and the protease inhibitor U-75875 were compared in two culture models of human immunodeficiency virus type 1 brain infection. In a model involving acutely infected microglial cells, U-90152 was the most active, whereas in a model using chronically infected promonocytes, U-75875 was the most active.

• Authors: P K Peterson, G Gekker, S Hu, C C Chao
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 38 Issue 10 Pg. 2465-8 (Oct 1994) ISSN: 0066-4804 [Print] United States
• PMID: 7530933 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antiviral Agents
• HIV Protease Inhibitors
• Indoles
• Oligopeptides
• Piperazines
• Reverse Transcriptase Inhibitors
• Tumor Necrosis Factor-alpha
• U 75875
• Delavirdine

Topics

• Antiviral Agents (pharmacology)
• Brain (virology)
• Cells, Cultured
• Delavirdine
• HIV Protease Inhibitors (pharmacology)
• HIV-1 (drug effects)
• Humans
• Indoles (pharmacology)
• Oligopeptides (pharmacology)
• Piperazines (pharmacology)
• Reverse Transcriptase Inhibitors
• Tumor Necrosis Factor-alpha (biosynthesis)