Epstein-Barr virus induction of recombinase-activating genes RAG1 and RAG2.

Abstract

In experimental B-cell infections, Epstein-Barr virus induced sustained expression of V(D)J recombinase-activating genes RAG1 and RAG2, whose aberrant activity has been implicated in chromosomal translocations in B-cell neoplasms. In cell lines in which RAG1 and RAG2 were detected, virus integrated into cellular DNA rather than assumed the configuration of extrachromosomal episomes. Expression of the Epstein-Barr virus nuclear antigen 1 in transient transfection assays was sufficient to induce both recombinase-activating genes.

• Authors: S K Srinivas, J W Sixbey
• Journal: Journal of virology (J Virol) Vol. 69 Issue 12 Pg. 8155-8 (Dec 1995) ISSN: 0022-538X [Print] United States
• PMID: 7494341 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Viral
• DNA Primers
• DNA-Binding Proteins
• Epstein-Barr Virus Nuclear Antigens
• Trans-Activators
• DNA Nucleotidyltransferases
• VDJ Recombinases

Topics

• Antigens, Viral (metabolism)
• Base Sequence
• Burkitt Lymphoma
• Cell Line
• DNA Nucleotidyltransferases (biosynthesis)
• DNA Primers
• DNA-Binding Proteins (metabolism)
• Enzyme Activation
• Epstein-Barr Virus Nuclear Antigens
• Gene Expression Regulation, Enzymologic
• Gene Expression Regulation, Viral
• Herpesvirus 4, Human (genetics)
• Humans
• Molecular Sequence Data
• Polymerase Chain Reaction
• Restriction Mapping
• Trans-Activators (metabolism)
• Tumor Cells, Cultured
• VDJ Recombinases
• Virus Integration