Liquid ventilation in adults, children, and full-term neonates.

Abstract

We evaluated the safety and efficacy of partial liquid ventilation in a series of 19 adults, children, and neonates who were in respiratory failure and on extracorporeal life support. During partial liquid ventilation, the alveolar-arterial oxygen difference decreased from 590 (SE 25) to 471 (42) mm Hg (p = 0.0002) and static pulmonary compliance increased from 0.18 (0.04) to 0.29 (0.04) mL cm H2O-1 kg-1 (p = 0.0002). 11 patients (58%) survived. These preliminary data suggest that partial liquid ventilation can be safely used in patients with severe respiratory failure and may improve lung function.

• Authors: R B Hirschl, T Pranikoff, P Gauger, R J Schreiner, R Dechert, R H Bartlett
• Journal: Lancet (London, England) (Lancet) Vol. 346 Issue 8984 Pg. 1201-2 (Nov 04 1995) ISSN: 0140-6736 [Print] England
• PMID: 7475663 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Fluorocarbons
• Hydrocarbons, Brominated
• perflubron

Topics

• Adult
• Child
• Extracorporeal Membrane Oxygenation
• Fluorocarbons (therapeutic use)
• Humans
• Hydrocarbons, Brominated
• Infant, Newborn
• Lung Compliance
• Pulmonary Gas Exchange
• Respiration, Artificial (methods)
• Respiratory Distress Syndrome, Newborn (therapy)
• Respiratory Insufficiency (mortality, therapy)