Abstract |
Infection with Trichinella spiralis in mice was accompanied by allergic sensitization as evidenced by anaphylactic death after intravenous injection of the antigen. Pre-treatment of the animals with oxatomide, a new orally active anti-allergic drug, resulted in significant protection of the animals; the lowest effective dose of the compound was 1.25 mg/kg orally. In contrast to cyproheptadine, oxatomide offered little protection against serotonin toxicity in mice. The present data suggest that, in this model of systemic hypersensitivity, the anti-anaphylactic effect of oxatomide can be attributed mainly to inhibition of release of allergic mediators.
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Authors | F De Clerck, L Van Gorp, O Vanparijs, M Borgers, F Awouters |
Journal | Agents and actions
(Agents Actions)
Vol. 8
Issue 6
Pg. 568-71
(Dec 1978)
ISSN: 0065-4299 [Print] Switzerland |
PMID | 742554
(Publication Type: Journal Article)
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Chemical References |
- Piperazines
- Serotonin Antagonists
- Serotonin
- oxatomide
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Topics |
- Anaphylaxis
(etiology, prevention & control)
- Animals
- Male
- Mice
- Piperazines
(pharmacology)
- Serotonin
(toxicity)
- Serotonin Antagonists
- Trichinellosis
(immunology, physiopathology)
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