The effect of cismethrin on the rat dorsal root potentials.

Abstract

Dorsal root potentials were recorded from urethane-anaesthetised rats. Bicuculline, a recognised GABA antagonist, reduced the amplitude of the potential to 67% of control. Cismethrin, a synthetic pyrethroid insecticide, enhanced the potential to 142% of control values. The convulsions associated with cismethrin poisoning therefore are not produced by an antagonism of GABA-mediated inhibitory transmission.

• Authors: P R Smith
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 66 Issue 1 Pg. 125-8 (Aug 22 1980) ISSN: 0014-2999 [Print] Netherlands
• PMID: 7408960 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Insecticides
• Pyrethrins
• cismethrin
• Bicuculline

Topics

• Animals
• Behavior, Animal (drug effects)
• Bicuculline (metabolism)
• Blood Pressure (drug effects)
• Insecticides (pharmacology)
• Membrane Potentials (drug effects)
• Pyrethrins (pharmacology)
• Rats
• Spinal Nerve Roots (drug effects)