Abstract |
Two patients with chronic meningococcemia were found to lack hemolytic complement, one because of C6 deficiency, the other because of C7 deficiency. In both cases family studies were consistent with inheritance of the deficiencies as non-HLA-linked, autosomal co-dominant traits. Functional studies showed the deficient sera to support monocyte chemotaxis but not phagocytosis or lysis of meningococci. Both patients have remained well following antibiotic treatment.
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Authors | J D Clough, M L Clough, A Weinstein, L H Calabrese, L R Mansfield, P Gulick, T Gavan, W E Braun |
Journal | Archives of internal medicine
(Arch Intern Med)
Vol. 140
Issue 7
Pg. 929-33
(Jul 1980)
ISSN: 0003-9926 [Print] United States |
PMID | 7387302
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Complement C6
- Complement C7
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Topics |
- Adolescent
- Child, Preschool
- Complement C6
(analysis, deficiency)
- Complement C7
(analysis, deficiency)
- Humans
- Male
- Meningococcal Infections
(complications, immunology)
- Pedigree
- Sepsis
(complications, immunology)
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