Effect of diethylstilbestrol on plasma testosterone levels during 24 hours: study comparing doses of 1 and 5 mg. daily, and 1 mg. 3 times daily.

Abstract

A study was done on 30 patients with advanced adenocarcinoma of the prostate treated with diethylstilbestrol. Three groups of patients were given daily doses of 1, 5, and 1 times 3 mg. diethylstilbestrol, respectively. The study was confined to the effects of treatment on the levels of plasma testosterone by taking hormonal specimens every 4 hours for 24 hours. The results showed little difference of plasma testosterone among the groups under study and a statistical analysis showed no significant differences. Therefore, our study showed no appreciable advantage in the dosage spread over the day, compared to commonly used doses of 1 or 5 mg. diethylstilbestrol given in a single dosage.

• Authors: J Flores-Esteva, R Medina-Santillán, H Berea-Domínguez, J J Villalpando-Casas, M A Martínez-Romero, L R Navarrete, M E Martin-Lombard
• Journal: The Journal of urology (J Urol) Vol. 123 Issue 6 Pg. 887-9 (Jun 1980) ISSN: 0022-5347 [Print] United States
• PMID: 7382007 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Testosterone
• Diethylstilbestrol

Topics

• Adenocarcinoma (drug therapy)
• Diethylstilbestrol (administration & dosage, pharmacology, therapeutic use)
• Drug Administration Schedule
• Humans
• Male
• Prostatic Neoplasms (drug therapy)
• Testosterone (blood)