[Epithelial bladder tumor induction in rats with N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide].

Abstract

Among 20 white non-inbred rats of the "Rappolovo" nursery for laboratory animals of the USSR Academy of Medical Sciences, which were fed through all their life N-/4-(5-nitro-2-furyl)-2-thiazolyl/formamide in the concentration 0.188%, transition-cell vesical tumors developed in 4 animals at the 56th, 60th, 61st 70th week of the experiment. After 71--81 weeks since the onset of the experiment, cancer of this organ developed in the remaining 14 animals. The maximum total dose of the carcinogen was 14.4 g/ per rat. The maximum observation terms--567 days.

• Authors: N N Vlasov, G B Pliss, V V Balin
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 26 Issue 3 Pg. 63-7 ( 1980) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Induktsiia éitelial'nykh opukholeĭ mochevogo puzyria u krys N-(4-(5-nitro-2-furil)-2-tiazolil) formamidom.
• PMID: 7368659 (Publication Type: English Abstract, Journal Article)

Chemical References

• Formamides
• Thiazoles
• FANFT

Topics

• Animals
• Carcinoma, Transitional Cell (chemically induced)
• FANFT (adverse effects)
• Formamides (adverse effects)
• Male
• Neoplasms, Experimental (chemically induced, pathology)
• Papilloma (chemically induced)
• Rats
• Thiazoles (adverse effects)
• Time Factors
• Urinary Bladder Neoplasms (chemically induced, pathology)