The
antihypertensive effect of
acebutolol 400 mg and
hydrochlorothiazide 25 mg in combination have been assessed in 22 patients with mild, moderate and severe
hypertension. In the supine position, blood pressure went down from an average of 190/116 mm Hg to 147/91 mm Hg
after treatment, while in the standing position, blood pressure went down from an average of 188/117 mm Hg to 143/94 mm Hg. Age, sex and duration of
hypertension have no significant influence upon the
antihypertensive effect of this combination. Good results were obtained in 68% of the patients, fair results in 23% and poor results in another 9%. Compared with the use of
acebutolol alone, its combination with
hydrochlorothiazide showed better results. In mild
hypertension good results increased from 75% after
acebutolol only to 100% after this combination. In moderate
hypertension the percentage of good results increases from 47% to 60% and in severe
hypertension good results increased from 50% to 67%. Increase of decrease in heart rate had no relation to the
antihypertensive effect of this combination.