Abstract |
Sequential studies of cellular and humoral immunity were conducted in an infant with the Wiskott-Aldrich syndrome prior to and after a splenectomy for uncontrollable hemorrhage. All measures of cellular immunity showed gradual improvement during the 8-month period after surgery. Serum isohemagglutinins, diphtheria and tetanus antibodies, and the percentage of immunoglobulin-bearing B cells did not change significantly from presplenectomy values. The serum IgE concentration declined from a high of 10,800 IU/ml at 1 month postsplenectomy to a low of 860 IU/ml at 5 months after surgery and the IgG concentration gradually decreased from a high of 1880 mg/dl presplenectomy to a low of 620 mg/dl 8 months later. The platelet count ranged from 64,000 to 206,000/mm3 for the first 6 months after splenectomy. It decreased precipitously 6.5 months after the operation; at the same time there was a marked rise in platelet-bound IgG antibody (PB- IgG). The PB- IgG declined rapidly following vincristine therapy and, after another rise, declined more gradually following steroid therapy.
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Authors | A P Knutsen, W F Rosse, T R Kinney, R H Buckley |
Journal | Journal of clinical immunology
(J Clin Immunol)
Vol. 1
Issue 1
Pg. 13-9
(Jan 1981)
ISSN: 0271-9142 [Print] Netherlands |
PMID | 7334067
(Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Immunoglobulin G
- Vincristine
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Topics |
- Antibody Formation
- Blood Platelets
(immunology)
- Follow-Up Studies
- Humans
- Immunity, Cellular
- Immunoglobulin G
(biosynthesis)
- Infant
- Lymphocyte Activation
- Male
- Prospective Studies
- Rosette Formation
- Splenectomy
- Vincristine
(therapeutic use)
- Wiskott-Aldrich Syndrome
(drug therapy, immunology, therapy)
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