Abstract |
"In vivo" and "in vitro" action of 2 MPG on lymphocytotoxic activity was evaluated in 22 patients with CAH, 14 were HBsAg positive and 8 were negative. The test was performed with and without 2 MPG in the colture medium, and before and after treatment. HBsAg+ patients received 2 MPG treatment, while HBsAg- ones received immunosoppressive therapy and 4 of these were on 2 MPG treatment as well. Cytotoxic Index was reduced non-significantly by addition of 2 MPG in colture medium in both groups. 2 MPG treatment does not modify cytotoxic activity which is reduced by immunosoppressive therapy. These findings suggest a positive effect of 2 MPG on liver-cell metabolism with an increased resistence of the epatocyte to the "in vitro" lymphocytes aggression. Hence it may be suggested an association treatment with immunosoppressive agents and 2 MPG.
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Authors | M Mazzetti, G Guizzardi, R Meliconi, M Baraldini, M V Stancari, M Mazzoli, G F Stefanini |
Journal | Bollettino della Societa italiana di biologia sperimentale
(Boll Soc Ital Biol Sper)
Vol. 57
Issue 14
Pg. 1477-83
(Jul 30 1981)
ISSN: 0037-8771 [Print] Italy |
Vernacular Title | Effetto della 2 mercaptopropionilglicine (2 MPG) sull'attività citotossica contro epatociti di coniglio isolati e coltivati in vitro dei linfociti di soggetti con epatite cronicaz attiva. |
PMID | 7295410
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Amino Acids, Sulfur
- Hepatitis B Surface Antigens
- Immunosuppressive Agents
- Tiopronin
|
Topics |
- Amino Acids, Sulfur
(therapeutic use)
- Animals
- Chronic Disease
- Cytotoxicity Tests, Immunologic
- Hepatitis B
(drug therapy, immunology)
- Hepatitis B Surface Antigens
(analysis)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Liver
(drug effects)
- Rabbits
- Tiopronin
(therapeutic use)
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