[Hemodynamics and metabolic-energetic expenses of the influence of AR-L115 in patients with coronary artery disease (author's transl)].

Abstract

AR-L115 has been shown to substantially improve myocardial pump function in patients (pts) with advanced congestive cardiomyopathy by i.v. and by p.o.-route. Since AR-L115 effects on myocardial oxygen consumption (MVO2) and coronary blood flow (CSF) are unknown, the hemodynamic myocardial metabolic and ECG-responses to AR-L115 (2 mg/kg BW bolus) were monitored at the 9, 14 and 19-min interval in 7 patients coronary 3-vessel disease, exhibiting ischemia during pacing stress only. Maximal responses occurred at the 14th min after AR-L115. THere were (average) increases in cardiac index by 30%, in heart rate by 19%, in CSF by 39%, in MVO2 by 34%, and in dp/dt max by 27%. There were (average) decreases in peak systolic pressure by 13%, in PCW by 30%, in LVEDP by 42%, in systemic vascular resistance by 34%, and in coronary vascular resistance by 37%. All changes were significant (p less than 0.05). Unchanged (p greater than 0.05) remained myocardial lactate extraction, stroke work index, and stroke-index. The only moderate increase in MVO2 is possibly explained in that the increase in contractility was a least partially offset by the reductions in pre- and after load. The AR-L115-induced improved pump function was accompanied by moderate increases in MVO2 and CSF, but without evidence of myocardial ischemia.

• Authors: J Thormann, W Kramer, M Schlepper
• Journal: Zeitschrift fur Kardiologie (Z Kardiol) Vol. 70 Issue 5 Pg. 385-93 (May 1981) ISSN: 0300-5860 [Print] Germany
• Vernacular Title: AR-L115-induzierte Anderungen der Hämodynamik, des koronaren Blutflusses und des Energiemetabolismus bei Patienten mit koronarer Herzerkrankung.
• PMID: 7269726 (Publication Type: English Abstract, Journal Article)

Chemical References

• Imidazoles
• Lactates
• sulmazole
• Oxygen

Topics

• Cardiac Pacing, Artificial
• Coronary Circulation (drug effects)
• Coronary Disease (drug therapy)
• Electrocardiography
• Energy Metabolism (drug effects)
• Hemodynamics (drug effects)
• Humans
• Imidazoles (therapeutic use)
• Lactates (blood)
• Male
• Middle Aged
• Myocardial Contraction (drug effects)
• Oxygen (blood)