alpha-Tocopherol and serum lipoproteins.

Abstract

Twenty-six patients with clinically confirmed mammary dysplasia and five age-matched controls were treated with alpha-tocopherol, 600 mg/day. Serum samples collected on the 21st day of the menstrual cycle were analyzed for cholesterol in lipoprotein fractions, isolated by a combination of precipitation and ultracentrifugation techniques. Eighty-five percent of patients showed objective and subjective remission from disease following therapy. In mammary dysplasia patients, the ratio of serum cholesterol/high density lipoprotein cholesterol was higher than those in age-matched controls, an abnormality which was corrected by alpha-tocopherol therapy. Furthermore, as a result of therapy, high density lipoproteins increased and ester cholesterol associated with low density lipoproteins decreased. The results suggest that alpha-tocopherol may serve as an effective agent in treating patients with benign disease, as well as correct the inherent abnormality in serum cholesterol distribution in mammary dysplasia patients.

• Authors: G S Sundaram, R London, S Manimekalai, P P Nair, P Goldstein
• Journal: Lipids (Lipids) Vol. 16 Issue 4 Pg. 223-7 (Apr 1981) ISSN: 0024-4201 [Print] United States
• PMID: 7242274 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lipoproteins
• Lipoproteins, HDL
• Lipoproteins, LDL
• Lipoproteins, VLDL
• Vitamin E
• Cholesterol
• alpha-Tocopherol
• Tocopherols

Topics

• Breast Diseases (blood)
• Cholesterol (blood)
• Female
• Fibrocystic Breast Disease (blood, drug therapy)
• Humans
• Lipoproteins (blood)
• Lipoproteins, HDL (blood)
• Lipoproteins, LDL (blood)
• Lipoproteins, VLDL (blood)
• Tocopherols
• Vitamin E (analogs & derivatives, therapeutic use)
• alpha-Tocopherol (analogs & derivatives)