Three hyperlipemic models in rats were compared regarding serum
lipid levels and known anti-hyperlipemic agents were tested for their effects on the
hyperlipemia. In rats fed a
cholesterol diet (group A), only serum
cholesterol level resulted in a marked increase as compared with normal level. In animals given a large dose (0.7 ml/100 g
body weight, i.v.) of anti-kidney serum (group B), extremely high elevations of serum total
lipid,
phospholipid,
triglyceride and
cholesterol levels were observed. In animals given a small dose (0.3 ml/100 g
body weight, i.v.) of anti-kidney serum and fed the
cholesterol diet (group C), elevations of these serum
lipids except for
triglyceride were not only greater than in group B, but also synergistic. On the contrary, serum
triglyceride level and
proteinuria were less in group C than in group B.
Furazabol,
clofibrate the
beta-sitosterol given orally for 7 days at doses of 1,100 and 500 mg/kg/day, respectively were clearly effective on the
hyperlipemia of group C, without affecting the
proteinuria. Furthermore, this model was more sensitive to these anti-hyperlipemic agents than groups A and B. From the above results, group C would seem to be an adequate and effective experimental hyperlipemic model.