Abstract |
Determination of the acute oral medial lethal dose (LD50) of haloxon for lambs classified as to the presence or absence of plasma esterases (A esterase; EsA) rapidly hydrolyzing haloxon revealed markedly different values for the 2 phenotypes of sheep. The LD50 for EsA- lambs was 763 mg/kg of body weight with 95% confidence limits of 543 to 1,072 mg/kg. The acute oral LD50 for EsA+ lambs remains undetermined but was demonstrated to be in excess of 11,392 mg/kg. The acute oral LD50 for a closely related organophosphate ( coumaphos) was not different in the 2 phenotypes of sheep.
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Authors | N F Baker, R A Fisk, C Stormont |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 41
Issue 11
Pg. 1857-9
(Nov 1980)
ISSN: 0002-9645 [Print] United States |
PMID | 7212416
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anthelmintics
- Insecticides
- Organophosphorus Compounds
- Umbelliferones
- Esterases
- Coumaphos
- haloxon
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Topics |
- Administration, Oral
- Animals
- Anthelmintics
(administration & dosage)
- Coumaphos
(toxicity)
- Esterases
(blood)
- Insecticides
(toxicity)
- Lethal Dose 50
- Organophosphorus Compounds
(toxicity)
- Sheep
(blood)
- Sheep Diseases
(chemically induced)
- Umbelliferones
(toxicity)
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