Analysis of organic acids in the hearts of patients with idiopathic cardiomyopathy by gas chromatography-mass spectrometry.

Abstract

Organic acids in the hearts of patients with idiopathic cardiomyopathy, obtained by biopsy, were studied using gas chromatography--mass spectrometry. The profiling of organic acids was compared among eight cases of hypertrophic cardiomyopathy, three cases of congestive cardiomyopathy, and nine cases of other heart diseases, which were regarded as controls. It was found that almost all organic acids, especially deoxyaldonic acids of 2-deoxytetronic acid, 2,3-dideoxypentonic acid, 3-deoxy-2-C-(hydroxymethyl)tetronic acid, 3-deoxyerythropentonic acid and 3-deoxy-2-C-(hydroxymethyl)erythropentonic acid, were accumulated in large amounts in the heart in congestive cardiomyopathy, while these acids were decreased in hypertrophic cardiomyopathy. It was therefore suggested that deoxyaldonic acid metabolism in the heart in congestive cardiomyopathy is quite different from that in hypertrophic cardiomyopathy.

• Authors: S Haraguchi, M Terasawa, H Toshima, I Matsumoto, T Kuhara, T Shinka
• Journal: Journal of chromatography (J Chromatogr) Vol. 230 Issue 1 Pg. 7-14 (Jun 11 1982) Netherlands
• PMID: 7202014 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carboxylic Acids

Topics

• Carboxylic Acids (analysis)
• Cardiomyopathy, Hypertrophic (metabolism)
• Gas Chromatography-Mass Spectrometry
• Heart Failure (metabolism)
• Humans
• Myocardium (analysis, metabolism)
• Reference Values