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Protective effects of butylated hydroxyanisole, ethoxyquin, and disulfiram on acute pyrrolizidine alkaloids poisoning in mice.

Abstract
Administration of butylated hydroxyanisole (BHA), ethoxyquin (EQ), and disulfiram (DSF) in the diet for 7 days reduced the acute toxicity of pyrrolizidine alkaloids isolated from Senecio longilobus. The LD50 values of the BHA- and EQ-fed mice were about twofold of the controls but the protective effect of DSF was inferior to that of either BHA or EQ.
AuthorsH L Kim, L P Jones
JournalResearch communications in chemical pathology and pharmacology (Res Commun Chem Pathol Pharmacol) Vol. 36 Issue 2 Pg. 341-4 (May 1982) ISSN: 0034-5164 [Print] United States
PMID7100635 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anisoles
  • Pyrrolizidine Alkaloids
  • Quinolines
  • Butylated Hydroxyanisole
  • Ethoxyquin
  • Disulfiram
Topics
  • Animals
  • Anisoles (pharmacology)
  • Butylated Hydroxyanisole (pharmacology)
  • Disulfiram (pharmacology)
  • Drug Interactions
  • Ethoxyquin (pharmacology)
  • Lethal Dose 50
  • Mice
  • Pyrrolizidine Alkaloids (antagonists & inhibitors, poisoning)
  • Quinolines (pharmacology)
  • Time Factors

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