Structure-activity relationship study of anthraquinones: 1,4-dihydroxy-5,8-bis[[2-(2-hydroxyethoxy)ethyl]amino]-9,10-anthracenedione, an analog of an established antineoplastic agent.

Abstract

An oxygen analog of the antineoplastic anthraquinone, 1,4-dihydroxy-5,8-bis[[2-(2-hydroxyethyl)amino]ethyl]amino - 9,10-anthracenedione, was synthesized. This compound, 1,4-dihydroxy-5,8-bis[[2-(2-hydroxyethoxy)ethyl]amino] - 9,10-anthracenedione, was found to be inactive against P-388 lymphocytic leukemia. A comparative structure-activity study of these two anthraquinones in terms of previously postulated N--O--O triangulation hypothesis was discussed.

• Authors: R K Zee-Cheng, C C Cheng
• Journal: Journal of pharmaceutical sciences (J Pharm Sci) Vol. 71 Issue 6 Pg. 708-9 (Jun 1982) ISSN: 0022-3549 [Print] United States
• PMID: 7097541 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anthraquinones
• Antineoplastic Agents
• 1,4-dihydroxy-5,8-bis((2-(2-hydroxyethoxy)ethyl)amino)-9,10-anthracenedione
• Mitoxantrone

Topics

• Animals
• Anthraquinones (chemical synthesis, pharmacology)
• Antineoplastic Agents (chemical synthesis)
• Leukemia L1210 (drug therapy)
• Leukemia P388 (drug therapy)
• Mice
• Mitoxantrone (analogs & derivatives)
• Structure-Activity Relationship