[Activity of di-N-hydroxyquinoxaline and depot-sulfanilamide derivatives in experimental NAG infection].

Abstract

In experiments in vitro dioxidineeee was highly effective as regards all the test cultures of NAG-vibrios. The MTC ranged within 1 to 62 micrograms/ml. Bactericidal action of the drug became manifest at concentrations from 4 to 250 micrograms/ml. The derivatives of di-N-oxide quinoxaline, dioxidin and quinoxidine exerted a chemotherapeutic effect and sterilizing action in experimental NAG-infection. The action of the drugs was potentiated upon combined use with lysozyme. As far as depo-sulfanilamides are concerned, sulfalenee was little active, while sulfamonomethoxine ineffective in experimental NAG-infection.

• Authors: A P Avtsyn, G N Pershin, R S Trager, V A Shakhlamov, E N Padeĭskaia
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 93 Issue 5 Pg. 76-8 (May 1982) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Aktivnost' proizvodnykh di-N-oksikhinoksalina i depo-sil'fanilamidov pri éksperimental'noĭ NAG-infektsii.
• PMID: 7093514 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents
• Delayed-Action Preparations
• Quinoxalines
• Sulfanilamides
• quinoxidine
• dioxidine
• Muramidase
• Sulfalene
• Sulfamonomethoxine

Topics

• Animals
• Anti-Infective Agents (therapeutic use)
• Delayed-Action Preparations
• Drug Evaluation, Preclinical
• Drug Therapy, Combination
• Mice
• Muramidase (therapeutic use)
• Quinoxalines (therapeutic use)
• Sulfalene (therapeutic use)
• Sulfamonomethoxine (therapeutic use)
• Sulfanilamides (therapeutic use)
• Vibrio Infections (drug therapy, microbiology)