Abstract |
Carminomycin (CMN) was administered i.v. to 44 patients with a variety of nonhematological cancers every 4 weeks at doses of 15, 20, 22.5, and 25 mg/sq m. Granulocytopenia was the dose-limiting toxicity. The median granulocyte count for previously untreated patients receiving 22.5 mg/sq m was 0.962 cells/microliters, and for previously treated patients receiving 20 mg/sq m it was 0.420 cell/microliters. Moderate to severe phlebitis was associated with drug administration in 50% of cases. Nausea, vomiting, and alopecia were mild. Three of nine patients who received a total CMN dose of greater than or equal to 100 mg/sq m (mean, 132 mg/sq m) developed unexplained decreases in radionuclide cardiac ejection fraction, with one patient developing decreased QRS amplitude and congestive heart failure at a total dose of 160 mg/sq m. CMN is rapidly metabolized to carminomycinol. The elimination half-lives of CMN and carminomycinol are 6 to 10 and 50 hr, respectively. CMN was found to be a more potent inhibitor of human granulocyte-macrophage colony-forming units than was carminomycinol. Objective partial responses were seen in two of seven previously untreated patients with non-small cell lung cancer and one of three patients with squamous cell carcinoma of the head and neck previously untreated with chemotherapy.
|
Authors | R L Comis, B F Issell, K Pittman, S J Ginsberg, A Rudolph, J C Aust, S M DiFino, R W Tinsley, B J Poiesz, S T Crooke |
Journal | Cancer research
(Cancer Res)
Vol. 42
Issue 7
Pg. 2944-8
(Jul 1982)
ISSN: 0008-5472 [Print] United States |
PMID | 7083181
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- dihydrocarminomycin
- Carubicin
- Daunorubicin
|
Topics |
- Adult
- Aged
- Agranulocytosis
(chemically induced)
- Carubicin
(administration & dosage, adverse effects, analogs & derivatives, blood, pharmacology)
- Colony-Forming Units Assay
- Daunorubicin
(analogs & derivatives)
- Drug Evaluation
- Female
- Heart Diseases
(chemically induced)
- Humans
- Infusions, Parenteral
- Male
- Middle Aged
- Neoplasms
(blood, drug therapy)
|