An open study of acebutolol, given as a single daily dose in the management of hypertension in the Chulalungkorn Hospital, Thailand.

Abstract

In an open study of fifteen patients with essential hypertension, acebutolol, a cardioselective B 1-adrenoceptor antagonist given orally once daily at dosages of between 400 mg and 1200 mg, produced a substantial and progressive reduction in systolic and diastolic arterial pressure and in the tension time index both in the lying and standing position over the 3 months of the trial. The changes from pre-trial values of blood pressure assessments were statistically significant (p less than 0.001). No side-effects were reported and laboratory monitoring of biological parameters revealed no untoward effects of treatment.

• Authors: C Ongcharit, J Goulton, P G Baker
• Journal: The Journal of international medical research (J Int Med Res) Vol. 8 Issue 3 Pg. 188-92 ( 1980) ISSN: 0300-0605 [Print] England
• PMID: 6993251 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Acebutolol

Topics

• Acebutolol (administration & dosage, therapeutic use)
• Administration, Oral
• Adult
• Clinical Trials as Topic
• Female
• Humans
• Hypertension (drug therapy)
• Male
• Middle Aged