Tolciclate versus miconazole, a double-blind trial in patients with dermatomycosis.

Abstract

Eighty-one patients with dermatomycosis such as tinea corporis, tinea cruris, tinea pedis and pityriasis versicolor were treated with tolciclate 1% cream or miconazole 2% cream. Parasitological cure was obtained in 100% of the patients given tolciclate and in 97.4% of those given miconazole. Patients and investigator considered tolciclate treatment as excellent, respectively, in 76.2% and 73.8% of the cases. The corresponding figures for miconazole were 74.4% and 66.7%. Both treatments were well tolerated.

• Authors: L C Cucè, B F Assunção, L G Medawar, A Salibian, W Groppi
• Journal: The Journal of international medical research (J Int Med Res) Vol. 8 Issue 2 Pg. 144-7 ( 1980) ISSN: 0300-0605 [Print] England
• PMID: 6989684 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Antifungal Agents
• Imidazoles
• Thiocarbamates
• Miconazole
• tolciclate

Topics

• Administration, Topical
• Adult
• Antifungal Agents (administration & dosage, therapeutic use)
• Clinical Trials as Topic
• Dermatomycoses (drug therapy)
• Double-Blind Method
• Female
• Humans
• Imidazoles (therapeutic use)
• Male
• Miconazole (administration & dosage, therapeutic use)
• Outcome and Process Assessment, Health Care
• Pityriasis (drug therapy)
• Thiocarbamates (therapeutic use)
• Tinea (drug therapy)
• Tinea Pedis (drug therapy)