Increased circulating T alpha lymphocyte population in bronchogenic and colonic carcinoma.

Abstract

The proportion of T lymphocytes bearing membrane receptors for IgA (T alpha cells) was markedly increased in the peripheral blood of patients suffering from cancers of the colon and bronchus compared to an age-matched normal population and to age-matched control patients being treated for non-malignant chronic inflammatory conditions of the intestine and lung. By contrast, the percentage of the T lymphocyte population having Fc-IgG receptors (T gamma cells) and Fc-IgM receptors (T mu cells) in mucosal malignancy was similar to that found in the two control populations. It is suggested that the increased percentage of T alpha cells found in colonic and bronchogenic carcinoma patients may reflect an as yet unknown regulatory function for this subset.

• Authors: A Pucci, R L Clancy, W F Doe
• Journal: Clinical and experimental immunology (Clin Exp Immunol) Vol. 46 Issue 1 Pg. 130-3 (Oct 1981) ISSN: 0009-9104 [Print] England
• PMID: 6978211 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunoglobulin A
• Receptors, Fc

Topics

• Carcinoma, Bronchogenic (immunology)
• Colonic Neoplasms (immunology)
• Humans
• Immunoglobulin A (immunology)
• Lung Neoplasms (immunology)
• Receptors, Fc (immunology)
• Rosette Formation
• T-Lymphocytes (immunology)