Elicitation of delayed-type hypersensitivity responses to poly(L-Tyr,LGlu)-poly(DLAla)--poly(LLys) by anti-idiotypic antibodies.

Abstract

The in vivo effect of murine anti-idiotypic serum against C3H.SW anti-poly(LTyr,LGlu)-poly(DLAla)-(LLys) [(T,G)-A--L] antibodies on delayed type hypersensitivity responses to (T,G)-A--L was studied. Anti-idiotypic serum could challenge DTH responses in C3H.SW mice transferred with antigen-sensitized T cells. The elicitation activity was shown to be antigen and strain specific. With H-2-compatible (but allotype different) strain combinations of (T,G)-A--L-educated T cells and recipients, we were able to show that the biological effect of the anti-idiotypic serum is expressed on the first antigen-sensitized idiotype-positive radioresistant T cell, but not on the proliferating normal cells of recipient origin that participate in the efferent phase of delayed-type hypersensitivity responses to (T,G)-A--L.

• Authors: G Strassmann, R Lifshitz, E Mozes
• Journal: The Journal of experimental medicine (J Exp Med) Vol. 152 Issue 5 Pg. 1448-52 (Nov 01 1980) ISSN: 0022-1007 [Print] United States
• PMID: 6968816 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Anti-Idiotypic
• Immunoglobulin Idiotypes
• Peptides

Topics

• Animals
• Antibodies, Anti-Idiotypic (immunology)
• Hypersensitivity, Delayed (immunology)
• Immunoglobulin Idiotypes (immunology)
• Lymphocyte Activation
• Mice
• Mice, Inbred Strains
• Peptides (immunology)
• Species Specificity
• T-Lymphocytes (immunology)