Cross-resistance of cultured murine leukemia vincristine-resistant P388 cells to vinblastine, vindesine, and bis (N-ethylidene vindesine) disulfide, disulfate.

Abstract

Cultured P388 leukemia cells derived from vincristine (VCR)-resistant cell populations developed in vivo in (C57BL X DBA/2)F1 mice (P388/VCR) were cross-resistant to vinblastine (VLB), vindesine (VDS), and bis(N-ethylidene vindesine)disulfide, disulfate (bis-VDS). Cross-resistance was a function of concentration and time of exposure. Cultured P388/VCR cells were more sensitive to 6.1x10-5Mbis- VDS than to 6.1x10-5MVDS or to 6.1x10-5MVLB. Cultured P388 cells derived from VCR-sensitive P388 leukemia passaged in vivo (P388/0)were significantly more sensitive to VDS and bis-VDS than to VLB. This degree of difference in sensitivity was also a function of concentration and time of exposure.

• Authors: L J Wilkoff, E A Dulmadge
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 68 Issue 6 Pg. 1023-6 (Jun 1982) ISSN: 0027-8874 [Print] United States
• PMID: 6953266 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents, Phytogenic
• Vincristine
• Vinblastine
• bis(N-ethylidene vindesine)disulfide
• Vindesine

Topics

• Animals
• Antineoplastic Agents, Phytogenic (pharmacology)
• Cell Survival
• Cells, Cultured
• Dose-Response Relationship, Drug
• Drug Resistance
• Leukemia P388 (pathology)
• Leukemia, Experimental (pathology)
• Mice
• Mice, Inbred C57BL
• Probability
• Vinblastine (analogs & derivatives, pharmacology)
• Vincristine (pharmacology)
• Vindesine