[Frequency of chromosome disorders occurring in human lymphocytes in the in vitro exposure to different doses of deuterons as protected by adeturon].

Abstract

Peripheral blood of 4 healthy donors was exposed to deutrons with the energy 4,2 GeV/nuclone and the intensivity of 4 to 6.10(10) particles per impulse, the capacity of the dose being 0,008 Gr/sec. The LPE of deutrons was 2,14 MeV sm2/g. Irradiation doses were 0,26; 0,49; 0,97; 2,02; 3,80 Gr. 15-20 min prior to irradiation, the protector adeturone was added at a concentration of 550 micrograms/ml of blood. Chromosome aberrations were analyzed in protected and unprotected blood samples. The results were treated using the method of variance and regression analysis. The correlative correspondence between the number of chromosome aberrations and an approximate dose of actual irradiation was established as Y = 0,13 d + 6,55.10(-4) D2 for dicentrics and as 0,26 D + 12,6.10(-4) D2 + 4,5 for the total percentage of aberrations. The pattern of the dose - effect dependence was retained in protected samples. The calculated values of the factor of dose decrease confirmed antiirradiation properties of adeturone.

• Authors: M D Bulanova, B A Ivanov, M S Mileva, N I Ryzhov, V N Gerasimenko
• Journal: Genetika (Genetika) Vol. 18 Issue 7 Pg. 1164-8 (Jul 1982) ISSN: 0016-6758 [Print] Russia (Federation)
• Vernacular Title: Issledovanie chastoty vozniknoveniia khromosomnykh narusheniĭ v limfotsitakh cheloveka pri vozdeĭstvii in vitro razlichnykh doz deĭtronov pod zashchitoĭ adeturona.
• PMID: 6889553 (Publication Type: English Abstract, Journal Article)

Chemical References

• Radiation-Protective Agents
• beta-Aminoethyl Isothiourea
• Adeturon
• Adenosine Triphosphate
• Deuterium

Topics

• Adenosine Triphosphate (analogs & derivatives, pharmacology)
• Chromosome Aberrations
• Deuterium
• Dose-Response Relationship, Radiation
• Humans
• In Vitro Techniques
• Lymphocytes (drug effects, radiation effects)
• Radiation Tolerance
• Radiation-Protective Agents (pharmacology)
• beta-Aminoethyl Isothiourea (analogs & derivatives, pharmacology)