Lipid composition and de novo lipid biosynthesis of human palmar fat in Dupuytren's disease.

Abstract

Seventy-two surgically obtained Dupuytren's disease palmar-fat (DDPF) specimens and 18 location-matched specimens from patients not suffering from this disease (controls) were studied for their total lipid composition and de novo lipogenic activity. Incubation of "DDPF" with 1-[14C]acetate in oxygen produced [14C]palmitate and [14C]stearate in approximately equal yields as those obtained from "controls." No [14C]octanate was formed in any of the palmar-fat preparations. The lipids and fatty acid analysis revealed differences: (a) DDPF specimens were richer in free fatty acids, methyl esters of fatty acids and free-cholesterol than specimens of controls. (b) DDPF specimens contained less phospholipids. (c) DDPF specimens showed a significantly higher content of octanoate and other short-chain fatty acids than specimens of controls. The above findings are not incompatible with the results expected if some mild hypoxia occurred in DDPF; this has been suggested in the statistical correlations observed for this disease and alcoholism with liver involvement.

• Authors: J L Rabinowitz, L Ostermann Jr, F W Bora, J Staeffen
• Journal: Lipids (Lipids) Vol. 18 Issue 5 Pg. 371-4 (May 1983) ISSN: 0024-4201 [Print] United States
• PMID: 6877040 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fatty Acids
• Lipids
• Phospholipids
• Cholesterol

Topics

• Adipose Tissue (metabolism)
• Cholesterol (analysis)
• Chromatography, Gas
• Dupuytren Contracture (metabolism)
• Fatty Acids (analysis)
• Hand
• Humans
• Lipids (analysis, biosynthesis)
• Phospholipids (analysis)