Identification of 2-imidazolines as anti-sickling agents.

Abstract	The drugs tolazoline, clonidine, lofexidine, and fenmetozole were found to inhibit the gelation of hemoglobin S in the order of increasing effectiveness. Only the latter, however, reduced the sickling of red cells significantly and normalized the oxygen affinity of SS blood at 5-10 mM concentrations. Since this level of drug is lower than those reported for many other anti-sickling agents to achieve comparable effects, the 2-imidazoline class of compounds may provide important clues for the development of therapy for sickle cell anemia.
Authors	H Chang, S M Ewert, R L Nagel
Journal	Molecular pharmacology (Mol Pharmacol) Vol. 23 Issue 3 Pg. 731-4 (May 1983) ISSN: 0026-895X [Print] United States
PMID	6865916 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Antisickling Agents Gels Hemoglobin, Sickle Imidazoles Oxyhemoglobins oxyhemoglobin S fenmetazole Tolazoline Clonidine lofexidine
Topics	Anemia, Sickle Cell (blood) Antisickling Agents Clonidine (analogs & derivatives, pharmacology) Gels Hemoglobin, Sickle (metabolism) Humans Imidazoles (pharmacology) Kinetics Oxyhemoglobins (metabolism) Structure-Activity Relationship Tolazoline (pharmacology)

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