Effect of cyclo(Leu-Gly) on the supersensitivity of dopamine receptors in spontaneously hypertensive rats.

Abstract

Spontaneously hypertensive rats exhibited dopamine receptor supersensitivity as evidenced by a greater hypothermic response to apomorphine in comparison with normotensive Wistar-Kyoto rats. A single injection of cyclo(Leu-Gly) given prior to apomorphine administration did no alter apomorphine induced hypothermia in either the normotensive or the hypertensive rats. Chronic administration of cyclo(Leu-Gly) for 7 days did not affect apomorphine response in normotensive rats, but blocked the exaggerated response to apomorphine in the hypertensive rats. These studies suggest that cyclo(Leu-Gly) interacts with the dopamine receptors and that the central dopamine receptors may play a role in the pathophysiology of hypertension.

• Authors: H N Bhargava
• Journal: Life sciences (Life Sci) Vol. 32 Issue 18 Pg. 2131-7 (May 02 1983) ISSN: 0024-3205 [Print] Netherlands
• PMID: 6843287 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Dipeptides
• Neuropeptides
• Peptides, Cyclic
• Receptors, Dopamine
• cyclo(leucylglycine)
• Apomorphine

Topics

• Animals
• Apomorphine (pharmacology)
• Blood Pressure (drug effects)
• Body Temperature Regulation (drug effects)
• Dipeptides (pharmacology)
• Hypertension (physiopathology)
• Male
• Neuropeptides
• Peptides, Cyclic
• Rats
• Rats, Inbred Strains
• Rats, Mutant Strains
• Receptors, Dopamine (drug effects, physiology)
• Species Specificity