[Treatment with misonidazole and high voltage irradiation of xenotransplanted human carcinomas in nu/nu mice with thymic aplasia].

Abstract

An investigation was conducted in order to determine the effect of combined high voltage irradiation and the sensitizing drug misonidazole (Ro-07-0582) on human gynecologic carcinomas transplanted into nu/nu mice with thymic aplasia. Two carcinomas of the endometrium, two carcinomas of the ovaries, and one carcinoma of the cervix were submitted to Co-60 irradiation with and without misonidazole. The tumor growth was compared to that of control groups. The dosage and fractionation of the high voltage irradiation (2 x 5 Gy/week, total dose 60 Gy) were adapted to clinical data. Misonidazole (1 mg/kg body weight) was administered by intraperitoneal injection 15 minutes before the irradiation. Compared with the control animals, the locally irradiated tumors showed a slower growth or even a regression. The administration of misonidazole, however, did not produce significant differences in our five cases. Some reasons for this absence of the radiosensitizing effect of misonidazole are briefly discussed.

• Authors: W Kleine, S Stange, D Nagy, H A Ladner
• Journal: Strahlentherapie (Strahlentherapie) Vol. 158 Issue 8 Pg. 498-503 (Aug 1982) ISSN: 0039-2073 [Print] Germany
• Vernacular Title: Misonidazol und Hochvoltbestrahlung an xenotransplantierten menschlichen Karzinomen auf thymusaplastischen nu/nu-Mäusen.
• PMID: 6814020 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cobalt Radioisotopes
• Nitroimidazoles
• Misonidazole

Topics

• Animals
• Cobalt Radioisotopes (therapeutic use)
• Female
• Genital Neoplasms, Female (radiotherapy)
• Humans
• Mice
• Mice, Nude
• Misonidazole (therapeutic use)
• Neoplasm Transplantation
• Nitroimidazoles (therapeutic use)
• Ovarian Neoplasms (radiotherapy)
• Radiotherapy, High-Energy
• Uterine Cervical Neoplasms (radiotherapy)
• Uterine Neoplasms (radiotherapy)