Platelet adhesiveness to glass beads in liver disease.

Abstract

Patients with liver disease have abnormal platelet function. We have investigated the retention of platelets to glass beads in fulminant hepatic failure, cirrhosis and normal controls. Glass bead retention was significantly increased in fulminant hepatic failure (91.5 +/- 4.8%, n = 10) compared with controls (80.2 +/- 8.5%, n = 10) whereas it was significantly reduced in cirrhosis (46.2 +/- 26.8%, n = 10). The increased platelet adhesiveness might predispose to the formation of platelet aggregates in the blood observed during charcoal haemoperfusion in patients with fulminant hepatic failure.

• Authors: P G Langley, R D Hughes, R Williams
• Journal: Acta haematologica (Acta Haematol) Vol. 67 Issue 2 Pg. 124-7 ( 1982) ISSN: 0001-5792 [Print] Switzerland
• PMID: 6801894 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acetaminophen

Topics

• Acetaminophen (adverse effects)
• Chemical and Drug Induced Liver Injury (blood, etiology)
• Chronic Disease
• Glass
• Hemoperfusion (adverse effects)
• Hepatic Encephalopathy (blood)
• Hepatitis, Viral, Human (blood)
• Humans
• Liver Cirrhosis (blood)
• Liver Cirrhosis, Alcoholic (blood)
• Liver Diseases (blood)
• Liver Function Tests
• Platelet Adhesiveness