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Treatment of infected urinary stones in rats by a new hydroxamic acid, "N-(pivaloyl)glycinohydroxamic acid.

Abstract
The effectiveness of a new urease inhibitor, N-(pivaloyl)glycinohydroxamic acid, in the treatment of infected urinary stones was investigated. The hydroxamic acid markedly inhibited and alkalinisation of urine and stone formation when it was administered orally to rats with urinary tract infection caused by Proteus mirabilis; its inhibitory effect was potentiated by concomitant treatment with Cephalexin. This compound may become a useful medicine for the treatment of struvite stones.
AuthorsH Takeuchi, Y Okada, K Kobashi, O Yoshida
JournalUrological research (Urol Res) Vol. 10 Issue 4 Pg. 217-9 ( 1982) ISSN: 0300-5623 [Print] Germany
PMID6758273 (Publication Type: Journal Article)
Chemical References
  • Hydroxamic Acids
  • N-(pivaloyl)glycinohydroxamic acid
Topics
  • Animals
  • Hydroxamic Acids (therapeutic use)
  • Male
  • Proteus Infections (complications)
  • Proteus mirabilis
  • Rats
  • Rats, Inbred Strains
  • Urinary Calculi (drug therapy, etiology)
  • Urinary Tract Infections (complications)

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