Activity of 1-p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt in M 5076/73A ovarian reticular cell sarcoma of the mouse.

Abstract

1-p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt (DM-COOK) was tested on M 5076/73A (M5) mouse sarcoma at a dose of 40 or 50 mg/kg/day (Days 6--14) after im transplant of 7 x 10(5) cells, with or without surgical removal of the primary tumor on Day 14. Treatment at either dose level resulted in reduction of the primary tumor weight to around 50% of that in the controls, and striking antimetastatic effects were observed. When a dose of 40 or 50 mg/kg of DM-COOK was followed by surgery, there were 14% and 40% long-term survivors, respectively, but the higher dose caused about 30% toxic deaths. After iv injection of 10(3) or 10(5) M5 tumor cells, no artificial metastases appeared in DM-COOK-treated mice, whereas all control animals had metastatic involvement in the liver, spleen, ovaries, and kidneys.

• Authors: T Colombo, S Garattini, L Lassiani, M D'Incalci
• Journal: Cancer treatment reports (Cancer Treat Rep) Vol. 66 Issue 11 Pg. 1945-8 (Nov 1982) ISSN: 0361-5960 [Print] United States
• PMID: 6754075 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Triazenes
• 1-(4-carboxyphenyl)-3,3-dimethyltriazene

Topics

• Animals
• Cell Line
• Evaluation Studies as Topic
• Female
• Lymphoma, Large B-Cell, Diffuse (drug therapy)
• Mice
• Neoplasm Metastasis
• Neoplasms, Experimental (drug therapy, surgery)
• Ovarian Neoplasms (drug therapy, surgery)
• Triazenes (administration & dosage, therapeutic use)