Abstract |
The authors describe a case they have personally seen of pure gonadal dysgenesis with caryotype 46 XY (Swyers' syndrome) in which they found absence of HY antigen. They analysed the descriptions in the literature about this syndrome and show how this antigen is responsible for testicular differentiation. They show the place this syndrome has in the group of syndromes of bands and once again draw attention that there is a great risk of gonadoblastoma development when the Y chromosome is present and especially when the HY antigen is present. This means that these dysgenetic gonads should be removed surgically.
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Authors | F Cossard, J Saurel, M Berger-Pauquet, G Brun |
Journal | Journal de gynecologie, obstetrique et biologie de la reproduction
(J Gynecol Obstet Biol Reprod (Paris))
Vol. 13
Issue 2
Pg. 151-6
( 1984)
ISSN: 0368-2315 [Print] France |
Vernacular Title | Syndrome de Swyers. A propos d'un nouveau cas de dysgénésie gonadique pure à caryotype 46 XY. |
PMID | 6736590
(Publication Type: Case Reports, English Abstract, Journal Article)
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Topics |
- Adolescent
- Female
- Gonadal Dysgenesis
(genetics)
- Gonadal Dysgenesis, 46,XY
(genetics, surgery)
- Humans
- Ovarian Neoplasms
(etiology, genetics, surgery)
- Precancerous Conditions
(genetics, surgery)
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