[Metabolism of xenobiotics in the liver in acute hypoxia of intact mice and mice adapted to oxygen deficiency].

Abstract

Experiments on white mice were made to study the effect of acute hypoxia in intact and hypoxia adapted animals on the function of liver hydroxylases. It was shown that acute hypoxia (vacuum 462 Pa, exposure 120 min) leads to a decrease in the rate of amidopyrine demethylation by liver microsomal enzymes. Preadaptation to hypoxia reduces the depth of microsomal hydroxylation inhibition in response to hypoxia. Variation in the constant of substrate binding with the enzymatic complex plays in important role in the mechanism of microsomal oxidation inhibition in the liver under hypoxia. The concentration of the hemoproteins P = 450 and b5 does not undergo any substantial changes.

• Authors: O R Grek, A V Dolgov, E G Iziumov, V B Loktev
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1984 Jan-Feb Vol. 47 Issue 1 Pg. 98-101 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Metabolizm ksenobiotikov v pecheni pri ostroĭ gipoksii u intaktnykh i adaptirovannykh k nedostatku kisloroda mysheĭ.
• PMID: 6705909 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cytochromes
• Aminopyrine
• Proadifen
• Mixed Function Oxygenases
• Phenobarbital

Topics

• Acute Disease
• Adaptation, Physiological (drug effects)
• Aminopyrine (metabolism)
• Animals
• Cytochromes (metabolism)
• Hypoxia (enzymology)
• Liver (drug effects, enzymology)
• Male
• Mice
• Microsomes, Liver (drug effects, enzymology)
• Mixed Function Oxygenases (metabolism)
• Phenobarbital (pharmacology)
• Proadifen (pharmacology)
• Time Factors