The suppressive effect of piroxicam on autochthonous intestinal tumors in the rat.

Abstract

Male Lobund strain Sprague--Dawley (SD) rats respond to single doses of methylazoxymethanol acetate (MAM) with high incidence of intestinal tumors within 5 months. Some non-steroidal anti-inflammatory drugs (NSAIDs) can block the synthesis of prostaglandins (PGs) and also interfere with tumor growth. A new class of NSAID, piroxicam, was added to the feed of MAM-treated rats. When examined 150 days later, there was a significant reduction of tumor-bearing rats and of tumors/rat compared to controls on drug-free feed; and there was no evidence of toxicity.

• Authors: M Pollard, P H Luckert, M A Schmidt
• Journal: Cancer letters (Cancer Lett) Vol. 21 Issue 1 Pg. 57-61 (Nov 1983) ISSN: 0304-3835 [Print] Ireland
• PMID: 6640513 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Thiazines
• Piroxicam
• Methylazoxymethanol Acetate
• Indomethacin

Topics

• Animals
• Body Weight
• Diet
• Indomethacin (therapeutic use)
• Intestinal Neoplasms (chemically induced, drug therapy, pathology)
• Male
• Methylazoxymethanol Acetate
• Piroxicam
• Rats
• Rats, Inbred Strains
• Thiazines (pharmacology, therapeutic use)