The B cell IgM Fc receptor: further evidence for the B cell origin of "null" chronic lymphocytic leukemia.

Abstract

Fifty-three cases of chronic lymphocytic leukemia (CLL) were studied for the presence of the B cell IgM Fc receptor (Fc microR) using an aggregated IgM reagent. Restricted surface immunoglobulin, using conventional immunofluorescent techniques and FACS analysis, was detected in 43 cases (81%). The cells in the remaining ten cases (19%) expressed negligible surface immunoglobulin (slg-) and did not form E rosettes (E-), but this "null" subset clearly expressed the B cell Fc microR. The coincident membrane expression of the B1 antigen and the la-like antigen, as well as serial studies showing surface membrane light chain acquisition (in one patient), provided additional evidence for the B cell origin of this slg-E- subset. This subgroup of CLL appears to correspond phenotypically to a normal counterpart at a stage of B cell differentiation between the pre-B cell and the slgM+ early B cell. The B cell Fc microR appears to be a consistent and potentially useful marker for sl gE ("null") CLL.

• Authors: R A Rudders, P A Poldre
• Journal: Blood (Blood) Vol. 64 Issue 2 Pg. 375-9 (Aug 1984) ISSN: 0006-4971 [Print] United States
• PMID: 6611179 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Surface
• Receptors, Antigen, B-Cell
• Receptors, Fc
• Receptors, Immunologic
• immunoglobulin M receptor

Topics

• Antigens, Surface (analysis, genetics)
• B-Lymphocytes (classification, immunology, metabolism)
• Humans
• Leukemia, Lymphoid (genetics, immunology)
• Lymphocytes, Null
• Phenotype
• Receptors, Antigen, B-Cell (analysis)
• Receptors, Fc (analysis, genetics)
• Receptors, Immunologic (analysis, genetics)
• Rosette Formation