Sixty-four patients with stage IIB
essential hypertension were examined for the urinary excretion of
prostaglandins E2 and F2 alpha, natriuresis and diuresis in the control period and then on the 3rd, and the 12th-14th day of the treatment with
diuretics (furosemid, hypotiazid, oxodolin,
brinaldix). All
diuretics were found to alter the urinary PG excretion, with the degree of their effect depending on the type of the
drug, the route and duration of its administration. Furosemid, to a greater degree than other
diuretics, increased the urinary excretion of
PGE2 thus bringing down the
PGF2 alpha/
PGE2 ratio,
brinaldix increased
PGF2 alpha excretion whereas hypotiazid, in cases of its prolonged employment, reduced the excretion of both PGs, the
PGF2 alpha decrease being more prominent.
PGE2 contributed to a decrease in BP and to the development of natriuresis. The physiological effect of
PGF2 alpha depended on the status of the water-electrolyte balance in the body: in patients with IIB stage
essential hypertension it facilitated the development of natriuresis and BP decrease. When following the administration of the
diuretics the balance of
sodium and water in the body lowered,
PGF2 alpha caused the retention of
sodium and water in the body and did not affect the BP.