Gastrointestinal and cardiovascular effects of the prostaglandin analogue Hoe 260.

Abstract

Hoe 260 is a long-lasting and potent antisecretory and cytoprotective prostaglandin E2-analogue, having a favourable split between therapeutic gastric effects, effect on blood pressure and intestinal side effects; this compound could be a promising drug in ulcer therapy. (formula; see text)

• Authors: M Bickel, W Bartmann, G Beck, U Lerch, R Schleyerbach, B A Schölkens
• Journal: Biomedica biochimica acta (Biomed Biochim Acta) Vol. 43 Issue 8-9 Pg. S235-8 ( 1984) ISSN: 0232-766X [Print] Germany
• PMID: 6596097 (Publication Type: Journal Article)

Chemical References

• Prostaglandins E
• Prostaglandins E, Synthetic
• HOE 260
• Dinoprostone

Topics

• Animals
• Blood Pressure (drug effects)
• Dinoprostone
• Dogs
• Gastric Acid (metabolism)
• Gastric Juice (drug effects)
• Kinetics
• Male
• Prostaglandins E (pharmacology)
• Prostaglandins E, Synthetic (pharmacology)
• Rats
• Rats, Inbred Strains