Recent advances in factors that alter lipid metabolism in chronic renal failure.

Abstract

The following conclusions and speculations can be tentatively drawn from the changes in lipoprotein composition and metabolism: (1) The presence of apo B-48 in serum VLDL and the high serum apo A-IV concentrations indicate a greater than normal contribution of alimentary remnant particles to the hypertriglyceridemia of uremic patients, (2) The presence of apo E and C in triglyceride-enriched serum LDL, together with the triglyceride enrichment of all lipoproteins, probably stems from a deficiency of lipoprotein lipase (LPL) and hepatic lipase (HL) activity, (3) The decreased ratio of serum apo C-II/C-III in VLDL is at least in part responsible for the depressed activity of LPL, (4) The accumulation of lipoprotein particles with distorted apoprotein and lipid patterns (particularly beta-VLDL with enrichment in cholesterol) could be associated with an increased atherogenesis because a recent study has demonstrated a strong association between raised serum IDL and VLDL concentrations and the degree of coronary atherosclerosis, (5) The increased apo E content of VLDL and HDL in uremic patients could particularly point to a disturbed cholesterol metabolism because such lipoproteins could interact with LDL at apo B, E receptors, (6) The decrease in serum HDL-cholesterol has been shown to be strongly associated with atheromatous vascular disease, and this could also hold for uremic patients; however, it is probable that low serum HDL-cholesterol together with a diminished capacity to form cholesterol-rich, apo E containing HDL represents a decrease in the antiatherogenic defense of the organism rather than an increased atherogenic potential [21].

• Authors: T Drüeke, B Lacour, J B Roullet, J L Funck-Brentano
• Journal: Kidney international. Supplement (Kidney Int Suppl) Vol. 16 Pg. S134-8 (Dec 1983) ISSN: 0098-6577 [Print] United States
• PMID: 6588243 (Publication Type: Journal Article)

Chemical References

• Apolipoproteins
• Chylomicrons
• Lipoproteins
• Triglycerides

Topics

• Animals
• Apolipoproteins (blood)
• Arteriosclerosis (etiology)
• Chylomicrons (blood)
• Humans
• Hyperlipidemias (etiology)
• Hypolipoproteinemias (etiology)
• Kidney Failure, Chronic (metabolism)
• Lipid Metabolism
• Lipoproteins (blood)
• Male
• Rats
• Risk
• Triglycerides (blood)