[Pharmacokinetics of a fluoride-calcium preparation for the treatment of osteoporosis].

Abstract

The pharmacokinetics of fluoride and calcium were studied after administration of a combined fluoride and calcium preparation (Tridin) (1, 2 and 3 tablets) in 9 healthy male volunteers, using a cross-over study design. The total estimation of the pharmacokinetic data was performed by a simultaneous curve fitting to all single values, using a direct search procedure based on an open two-compartment model and three-compartment model, respectively. Maximum plasma concentrations and areas under the curve are proportional to the dose administered. Inter-subject variations are comparatively small, computerized multiple dose simulation for 3 days does not show any cumulation. The data fit the two-compartment model and the three-compartment model as well. The behaviour of the calcium concentrations reflects the immediate response of calcium homeostasis: plasma calcium concentrations are not affected.

• Authors: C Fuchs, W Haase, H Maurer
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 34 Issue 7 Pg. 832-5 ( 1984) ISSN: 0004-4172 [Print] Germany
• Vernacular Title: Pharmakokinetik eines Fluorid-Kalzium-Präparates zur Behandlung der Osteoporose.
• PMID: 6541921 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Combinations
• tridin
• Fluorides
• Calcium

Topics

• Adult
• Calcium (metabolism, therapeutic use)
• Drug Combinations (metabolism, therapeutic use)
• Fluorides (metabolism, therapeutic use)
• Humans
• Kinetics
• Male
• Osteoporosis (drug therapy)
• Time Factors