In vitro activity of WIN 49375 compared with those of other antibiotics in isolates from cancer patients.

Abstract

The activity of WIN 49375 [6-fluoro-1, 4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-3- quinolinecarboxylic acid], a new synthetic quinolone, was tested in vitro against 587 clinical isolates. The MICs for 90% of isolates of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae were 0.20, 1.56, and 0.39 microgram/ml, respectively. The MICs for 90% of isolates of Pseudomonas aeruginosa and Serratia marcescens were both 3.12 micrograms/ml. WIN 49375 was minimally active against gram-positive cocci. Its in vitro activity suggests that it may be useful for the treatment of gram-negative bacillary infections.

• Authors: I Garcia, G P Bodey, V Fainstein, D H Ho, B LeBlanc
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 26 Issue 3 Pg. 421-3 (Sep 1984) ISSN: 0066-4804 [Print] United States
• PMID: 6508271 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Anti-Infective Agents
• Fluoroquinolones
• Quinolines
• Ciprofloxacin
• amifloxacin

Topics

• Anti-Bacterial Agents (pharmacology)
• Anti-Infective Agents
• Bacteria (drug effects)
• Ciprofloxacin (analogs & derivatives)
• Fluoroquinolones
• Humans
• Microbial Sensitivity Tests
• Neoplasms (microbiology)
• Quinolines (pharmacology)