[Efficacy of intrapleural treatment with aclacinomycin combined with closed tube thoracostomy for malignant pleural effusion].

Abstract

Intrapleural treatment with aclacinomycin combined with closed tube thoracostomy was used in 7 patients with malignant pleural effusion. Five patients had no recurrence of effusion 3 months after the treatment. Aclacinomycin levels were much higher in blood cells than in plasma, and metabolites were present as the active form. We posit that the local instillation of aclacinomycin is indicated in the management of malignant pleural effusion.

• Authors: M Fujii, K Okabe, H Toki, Y Fujita, T Ishimitsu
• Journal: Gan no rinsho. Japan journal of cancer clinics (Gan No Rinsho) Vol. 30 Issue 8 Pg. 895-8 (Jul 1984) ISSN: 0021-4949 [Print] Japan
• PMID: 6471394 (Publication Type: English Abstract, Journal Article)

Chemical References

• Naphthacenes
• aclacinomycins
• Aclarubicin

Topics

• Aclarubicin (analogs & derivatives)
• Adenocarcinoma (complications)
• Adult
• Aged
• Drainage (methods)
• Female
• Humans
• Intubation
• Lung Neoplasms (complications)
• Male
• Middle Aged
• Naphthacenes (administration & dosage)
• Pleural Effusion (metabolism)
• Thorax