Treatment of acne vulgaris comparing two similar lotion formulations, one with ('Actinac') and one without chloramphenicol.

Abstract

A double-blind, randomized study was carried out in 37 patients with acne vulgaris to compare the efficacy of two similar lotion formulations, one with ('Actinac') and the other without chloramphenicol (4%). Patients used one or other of the two formulations twice daily for the first 4 days and then at night only for the remainder of the 3-month trial period. At the end of the first month's treatment, the group treated with the full formulation showed a statistically significant greater reduction in lesion count score than in the group receiving the formulation without chloramphenicol. Both treatments produced statistically significant reductions in lesion counts at all monthly follow-up visits. After 3-months' treatment, the mean lesion count score was reduced from 28.8 to 9.3 in the full formulation-treated group and from 39.5 to 14.3 in the formulation minus chloramphenicol group, but this difference did not reach statistical significance.

• Authors: N B Fraser, R A Main, T W Stewart, E J Thornton
• Journal: Current medical research and opinion (Curr Med Res Opin) Vol. 6 Issue 7 Pg. 461-5 ( 1980) ISSN: 0300-7995 [Print] England
• PMID: 6444862 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents
• Drug Combinations
• Excipients
• Nicotinic Acids
• Allantoin
• hydrocortisone acetate
• Chloramphenicol
• Sulfur
• Hydrocortisone

Topics

• Acne Vulgaris (drug therapy)
• Administration, Topical
• Allantoin (administration & dosage, therapeutic use)
• Anti-Inflammatory Agents (therapeutic use)
• Chemical Precipitation
• Chloramphenicol (administration & dosage, therapeutic use)
• Double-Blind Method
• Drug Combinations
• Excipients (therapeutic use)
• Female
• Humans
• Hydrocortisone (analogs & derivatives, therapeutic use)
• Male
• Nicotinic Acids (administration & dosage, therapeutic use)
• Sulfur (administration & dosage, therapeutic use)