Antiepileptic action of the beta-carboline ZK 91296 in a genetic petit mal model in rats.

Abstract

The anticonvulsant action of the benzodiazepine (BZ) receptor partial agonist, ethyl 5-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylate (ZK 91296) was studied in rats of Wistar origin exhibiting spontaneous bilateral cortical synchronous spike and wave discharges with a symptomatology paralleling that of human petit mal seizures. ZK 91296 1-16 mg/kg i.p.) attenuated the absence seizures without inducing signs of sedation or disorganized EEG patterns at any dose. Diazepam (1-8 mg/kg i.p.) suppressed seizures but also induced sedation and modified EEG background activity in a dose-related manner.

• Authors: L H Jensen, C Marescaux, M Vergnes, G Micheletti, E N Petersen
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 102 Issue 3-4 Pg. 521-4 (Jul 20 1984) ISSN: 0014-2999 [Print] Netherlands
• PMID: 6436039 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Carbolines
• Indoles
• ZK 91296
• Diazepam

Topics

• Animals
• Anticonvulsants
• Behavior, Animal (drug effects)
• Carbolines (pharmacology)
• Diazepam (pharmacology)
• Dose-Response Relationship, Drug
• Electroencephalography
• Epilepsy, Absence (drug therapy)
• Indoles (pharmacology)
• Male
• Rats
• Rats, Inbred Strains