Relative uptake of low- and high-osmolality contrast media in CT of brain tumors.

Abstract

The magnitude and time course of contrast enhancement in spontaneous canine brain tumors was determined for two contrast agents: meglumine iothalamate and sodium meglumine ioxaglate. Tumor enhancement during contrast infusion and at 5, 10, 15, 30, and 45 min was measured using quantitative computed tomography. Blood iodine was measured using x-ray fluorescence. Peak contrast enhancement occurred during the infusion, and the magnitude was the same for both agents. Per gram of iodine infused, blood iodine was 12.4% higher with ioxaglate than iothalamate. The monoionic dimer ioxaglate is as effective as iothalamate for enhancement of canine brain tumors.

• Authors: J R Fike, C E Cann, D Norman, J M Turrel, R A LeCouteur, C M Pflugfelder, J K Borcich
• Journal: AJNR. American journal of neuroradiology (AJNR Am J Neuroradiol) 1984 Jul-Aug Vol. 5 Issue 4 Pg. 413-7 ISSN: 0195-6108 [Print] United States
• PMID: 6431776 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Contrast Media
• Triiodobenzoic Acids
• Iodine
• Iothalamate Meglumine
• Ioxaglic Acid

Topics

• Animals
• Brain Neoplasms (diagnostic imaging)
• Contrast Media (metabolism)
• Dogs
• Iodine (blood)
• Iothalamate Meglumine (metabolism)
• Ioxaglic Acid
• Kinetics
• Osmolar Concentration
• Time Factors
• Tomography, X-Ray Computed
• Triiodobenzoic Acids (metabolism)