The antigen of mature human B cells detected by the monoclonal antibody FMC7: studies on the nature of the antigen and modulation of its expression.

Abstract

The monoclonal antibody FMC7 delineates a subpopulation of B lymphocytes in normal blood. Expression of the antigen recognized by FMC7 appears to be maturation-linked, and it serves to distinguish different types of B cell leukemia. The data presented here indicate that the antigen is a protein that is integrated in the cell membrane and that is able to interact with the cytoskeleton. The antigen is rapidly synthesized and turned over, is not cell cycle-dependent, and is relatively resistant to changes induced by culture in the presence of a phorbol ester.

• Authors: H Zola, H A Moore, A Hohmann, I K Hunter, A Nikoloutsopoulos, J Bradley
• Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 133 Issue 1 Pg. 321-6 (Jul 1984) ISSN: 0022-1767 [Print] United States
• PMID: 6427340 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Antigens, Differentiation, B-Lymphocyte
• Antigens, Neoplasm
• Antigens, Surface

Topics

• Antibodies, Monoclonal (immunology)
• Antigen-Antibody Reactions
• Antigens, Differentiation, B-Lymphocyte
• Antigens, Neoplasm (analysis, immunology)
• Antigens, Surface (analysis, immunology)
• B-Lymphocytes (cytology, immunology)
• Cell Cycle
• Cell Differentiation
• Cell Line
• Cell Transformation, Neoplastic (immunology)
• Humans
• Immunologic Capping