Abstract |
70 psychiatric patients were treated with a depot preparation of cis (Z) clopenthixol decanoate, a new sedative and anti-psychotic neuroleptic. The mean dosage interval was two weeks, an amount of drug from 50 to 1000 mg for each I.M. injection. Significant improvements were obtained on thinking disturbance, hostile-suspiciousness and anxious-depression symptoms groups. Thus, paranoid schizophrenia seems the best indication of cis (Z) clopenthixol decanoate. Side effects ( parkinsonism, weight increase) were of low intensity, and no depression was observed. This new long-acting depot neuroleptic may be used not only in hospitalized chronic schizophrenic patients, but also in outpatients as maintenance treatment: excellent results were obtained in such patients with a very low (less than 200 mg) fortnightly dosage. Advantages and indications of cis (Z) clopenthixol decanoate are discussed.
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Authors | P A Lambert, J P Chabannes |
Journal | L'Encephale
(Encephale)
Vol. 10
Issue 2
Pg. 83-91
( 1984)
ISSN: 0013-7006 [Print] France |
Vernacular Title | Un nouveau neuroleptique retard injectable à action sédative et anti-psychotique: le décanoate de cis (Z) clopenthixol. Essais cliniques. |
PMID | 6381033
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Delayed-Action Preparations
- Thioxanthenes
- clopenthixol decanoate
- Clopenthixol
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Topics |
- Adult
- Aged
- Clinical Trials as Topic
- Clopenthixol
(administration & dosage, analogs & derivatives, metabolism, therapeutic use)
- Delayed-Action Preparations
- Female
- Humans
- Injections, Intramuscular
- Male
- Mental Disorders
(drug therapy)
- Middle Aged
- Thioxanthenes
(therapeutic use)
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