Thymosin alpha 11: a peptide related to thymosin alpha 1 isolated from calf thymosin fraction 5.

Abstract

Two peptides related to thymosin alpha 1 have been isolated from preparations of calf thymosin fraction 5. One, lacking four amino acid residues at the COOH terminus, is designated des-(25-28)-thymosin alpha 1. The other, named thymosin alpha 11, contains seven additional amino acid residues at the COOH terminus. The sequence of this peptide is: AcSer-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu- Lys-Glu-Lys- Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Gly-Arg-Glu-Ala-Pro-Ala-AsnOH. Thymosin alpha 11, in doses of less than 300 ng per mouse, protects susceptible inbred murine strains against opportunistic infections with Candida albicans. It is approximately equal to 30 times as potent as thymosin fraction 5 and approximately equal in potency to thymosin alpha 1.

• Authors: J Caldarella, G J Goodall, A M Felix, E P Heimer, S B Salvin, B L Horecker
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 80 Issue 24 Pg. 7424-7 (Dec 1983) ISSN: 0027-8424 [Print] United States
• PMID: 6369316 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Amino Acids
• thymosin fraction 5
• Thymosin
• thymosin alpha(11)
• Thymalfasin

Topics

• Amino Acid Sequence
• Amino Acids (analysis)
• Animals
• Candida albicans (drug effects, growth & development)
• Cattle
• Chromatography, High Pressure Liquid
• Mice
• Mice, Inbred Strains
• Thymalfasin
• Thymosin (analogs & derivatives, isolation & purification, toxicity)