Effects of intravenous endralazine in essential hypertension.

Abstract

The effects of endralazine, administered intravenously, on blood pressure, heart rate, forearm blood flow, plasma renin activity, aldosterone, adrenaline and noradrenaline were studied in five patients with essential hypertension. Endralazine reduced peripheral vascular resistance, resulting in decrease in mean arterial pressure from 141 to 116 mm Hg and increase in heart rate from 67 to 92 beats/min. Plasma renin activity, adrenaline and noradrenaline increased significantly after endralazine infusion. All effects observed are consistent with endralazine acting as a peripheral vasodilating drug.

• Authors: J J Hoffmann, T Thien, A van T'Laar
• Journal: British journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 16 Issue 1 Pg. 39-44 (Jul 1983) ISSN: 0306-5251 [Print] England
• PMID: 6349669 (Publication Type: Journal Article)

Chemical References

• Antihypertensive Agents
• Pyridazines
• BQ 22-708
• Aldosterone
• Renin
• Norepinephrine
• Epinephrine

Topics

• Adult
• Aldosterone (blood)
• Antihypertensive Agents (administration & dosage, adverse effects)
• Blood Pressure (drug effects)
• Epinephrine (blood)
• Female
• Humans
• Hypertension (drug therapy)
• Male
• Middle Aged
• Norepinephrine (blood)
• Pyridazines (administration & dosage, adverse effects)
• Renin (blood)
• Time Factors